Gotteland M, Cruchet S. Suppressive effect of frequent ingestion of Lactobacillus johnsonii La1 on Helicobacter pylori colonization in asymptomatic volunteers. The results of the studies suggest that specific probiotics, such as S. boulardii and L. johnsonni La1 probably diminish the bacterial load, but not completely eradicate the H. pylori bacteria. Effectiveness of oral intake of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on Group B Streptococcus colonization during pregnancy: a midwifery-led double-blind randomized controlled pilot trial. Schultz M, Sartor RB. All rights reserved. A total of 70 treatment-naïve patients were randomly assigned into group A (the L. reuteri treated group) and group B (the placebo control group). Mucins are high-molecular-weight glycoproteins that protect the gastric epithelium. Expression of Lewisa, Lewisb, Lewisx, Lewisy, siayl-Lewisa, and sialyl-Lewisx blood group antigens in human gastric carcinoma and in normal gastric tissue. Efrati C, Nicolini G, Cannaviello C, O'Sed NP, Valabrega S. World J Gastroenterol. Shane AL, Mody RK, Crump JA, et al. Eur J Pediatr. The characteristics of important studies where probiotics were used as adjuvant therapy to eradication treatment are presented in Table Table11. • View abstract. In addition, the oral intake of probiotics may reinforce protective functions in the stomach. Epub 2018 Nov 16. The severity and activity of H. pylori associated gastritis were reduced after 4 weeks of therapy in both groups. Probiotics and gastrointestinal diseases. -, Blaser MJ. Lesbros-Pantoflickova D, Corthésy-Theulaz I, Blum AL. Int J Surg. Can J Infect Dis Med Microbiol. This situation needs the development of alternative treatment options for the H. pylori infection in patients. Mukai T, Asasaka T, Sato E, Mori K, Matsumoto M, Ohori H. Inhibition of binding of Helicobacter pylori to the glycolipid receptors by probiotic Lactobacillus reuteri. Eighty-six symptomatic children infected with H. pylori were randomized either to receive the omeprazole, amoxicillin, clarithromycin or the same regimen with addition of probiotic for 7 d. Eradication rate was statistically significantly higher in the probiotic group (P = 0.0045). The H. pylori is very closely associated with extracellular MUC5AC and epithelial cells that produce MUC5AC, therefore MUC5AC plays a role in the adherence of H. pylori to the gastric mucosa. Efficacy of Lactobacillus-supplemented triple therapy for Helicobacter pylori infection in children: a meta-analysis of randomized controlled trials. D’Elios MM, Czinn SJ. 8600 Rockville Pike 2014 Jan;7 (1):4-13. doi: 10.1177/1756283X13503514. Clipboard, Search History, and several other advanced features are temporarily unavailable. Effects of nonpathogenic bacteria on cytokine secretion by human intestinal mucosa. Lactobacillus reuteri is a species of probiotic bacteria. Yefet E, Colodner R, Strauss M, Gam Ze Letova Y, Nachum Z. Arch Dis Child Fetal Neonatal Ed. Bacterial factors that mediate colonization of the stomach and virulence of Helicobacter pylori. Helicobacter pylori infection. Am J Clin Nutr. Guarino A, Ashkenazi S, Gendrel D, Lo Vecchio A, Shamir R, Szajewska H; European Society for Pediatric Gastroenterology, Hepatology, and Nutrition; European Society for Pediatric Infectious Diseases. Probiotics: effects on immunity. Diabetes Obes Metab. Chang HY, Chen JH, Chang JH, Lin HC, Lin CY, Peng CC. Weizman Z, Abu-Abed J, Binsztok M. Lactobacillus reuteri DSM 17938 for the management of functional abdominal pain in childhood: A randomized, double-blind, placebo-controlled trial. Zhu R, Chen K, Zheng YY, Zhang HW, Wang JS, Xia YJ, Dai WQ, Wang F, Shen M, Cheng P, et al. Validation of the probiotic concept: Lactobacillus reuteri confers broad-spectrum protection against disease in humans and animals. J Matern Fetal Neonatal Med. It also mediates binding to salivary mucin MUC5B, a proline-rich glycoprotein, and to the glycoprotein gp-340[6]. Effect of whey-based culture supernatant of Lactobacillus acidophilus (johnsonii) La1 on Helicobacter pylori infection in humans. Yuan Y, Ford AC, Khan KJ, Gisbert JP, Forman D, Leontiadis GI, Tse F, Calvet X, Fallone C, Fischbach L, Oderda G, Bazzoli F, Moayyedi P. Cochrane Database Syst Rev. View abstract. Tenorio-Jiménez C, MartÃnez-RamÃrez MJ, Del Castillo-Codes I, et al. Open Forum Infect Dis 2017;4(2):ofx085. Similarly, Wang et al[52] revealed that after intake of B. lactis Bb12 and L. acidophilus La5 in H. pylori infected adults a decrease in urea breath test values was detected. H. pylori also induce humoral response of gastric mucosa, which may contribute to gastric mucosal damage. -, Mehling H, Busjahn A. Non-viable Lactobacillus reuteri DSMZ 17648 (Pylopass™) as a new approach to Helicobacter pylori control in humans. High cholesterol. Deguchi R, Nakaminami H, Rimbara E, Noguchi N, Sasatsu M, Suzuki T, Matsushima M, Koike J, Igarashi M, Ozawa H, et al. 2019;46(12):1217-1227. The eradication rate of H. pylori infection was 74.3% and 65.7% for both L. reuteri and placebo treated groups, respectively. Effect of Lactobacillus sakei supplementation in children with atopic eczema-dermatitis syndrome. Keywords: View abstract. The MUC5AC glycoprotein is the primary receptor for Helicobacter pylori in the human stomach. View abstract. Lipoteichoic acids in Lactobacillus strains that colonize the mouse gastric epithelium. L. reuteri has been recognized as a particular binding opponent of H. pylori compared to other Lactobacillus . L. reuteri is also a good candidate for adjunctive therapy, but more positive studies are needed. Applying a stringent screening procedure . 1st ed. OMP are adhesins on the surface of the bacteria, which promote binding to the epithelial cells in the stomach. Background: Lactobacillus reuteri is a probiotic that originated from humans and have been used for eradication of the Helicobacter pylori (HP) infection. Romano C, Ferrau' V, Cavataio F, et al. Ojetti V, Ianiro G, Tortora A, et al. The impacts of probiotics in eradication therapy of Helicobacter pylori. View abstract. See: http://creativecommons.org/licenses/by-nc/4.0/, P- Reviewer: D'Elios MM, Eren B, Malnick S, Sakarya S S- Editor: Yu J L- Editor: A E- Editor: Wang CH, National Library of Medicine Effect of pre-treatment with L. gasseri OLL2716 on first-line eradication therapy was studied in a trial published by Deguchi et al[77]. L. reuteri is a good alternative for patients with chronic dyspepsia for the eradication of H. pylori infection. View abstract. View abstract. Impact of Lactobacillus reuteri Supplementation on Anti-Helicobacter pylori Levofloxacin-Based Second-Line Therapy. Lorca GL, Wadström T, Valdez GF, Ljungh A. Lactobacillus acidophilus autolysins inhibit Helicobacter pylori in vitro. An official website of the United States government. Pelekos G, Ho SN, Acharya A, Leung WK, McGrath C. A double-blind, paralleled-arm, placebo-controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care. J Pediatr Gastroenterol Nutr 2014;58(1):81-6. Stensson M, Koch G, Coric S, Abrahamsson TR, Jenmalm MC, Birkhed D, Wendt LK. 2019;25(6):699-704. Bethesda, MD 20894, Web Policies The gastric inflammation can be controlled to some level by different strains of Lactobacilli through inactivating JAK2 through JAK– STAT pathways and through higher expression of SOCS protein family[36]. Helicobacter pylori (H. pylori) is a Gram-negative micro-organism. Duman DG, Bor S, Ozütemiz O, Sahin T, Oğuz D, Iştan F, Vural T, Sandkci M, Işksal F, Simşek I, et al. 2023 May 15;13:1120789. doi: 10.3389/fcimb.2023.1120789. Sharpe M, Shah V, Freire-Lizama T, et al. Lactobacilli vs antibiotics to prevent urinary tract infections: a randomized, double-blind, noninferiority trial in postmenopausal women. Lactobacillus reuteri DSM17648 was identified as a highly specific binding antagonist to H. pylori among more than 700 wild-type strains of Lactobacillus species. Guidelines for the evaluation of probiotics in food: joint FAO/WHO Working Group report on drafting guidelines for the evaluation of probiotics in food. H. pylori is highly adapted to special conditions in the stomach. Effects of non-viable Lactobacillus reuteri combining with 14-day standard triple therapy on Helicobacter pylori eradication: A randomized double-blind placebo-controlled trial. Antagonistic activity exerted in vitro and in vivo by Lactobacillus casei (strain GG) against Salmonella typhimurium C5 infection. No effect of probiotics on respiratory allergies: a seven-year follow-up of a randomized controlled trial in infancy. Evaluation of the Potential Protective Effects of, Development of probiotics beverage using cereal enzymatic hydrolysate fermented with. Several systematic reviews and meta-analyses regarding effect of probiotics as adjuvant therapy to standard treatment of H. pylori infection have been published[62,63]. Savino F, Pelle E, Palumeri E, et al. Patients were randomly divided into two equal groups (23 patients each group). Triple therapy of H. pylori supplemented with L. reuteri increased eradication rate by 8.6%, improved the GSRS score, reduced the reported side effects and improved the histological features of H. pylori infection when compared with placebo-supplemented triple therapy. Conclusion: Conflict-of-interest statement: The authors have no conflict of interest to declare. Lionetti E, Miniello VL, Castellaneta SP, Magistá AM, de Canio A, Maurogiovanni G, Ierardi E, Cavallo L, Francavilla R. Lactobacillus reuteri therapy to reduce side-effects during anti-Helicobacter pylori treatment in children: a randomized placebo controlled trial. Arch Intern Med 2012;172(9):704-12. official website and that any information you provide is encrypted The vegan formula includes an optimal balance of Lactobacillus paracasei (L. paracasei), Lactobacillus reuteri (L. reuteri), and clinically researched BLIS K-12 (Streptococcus salivarius), BLIS M-18 (Streptococcus salivarius) strains. L. acidophilus CRL 639 secret an autolysin, a proteinaceous compound released after cell lysis, which has some antibacterial activity[41]. The same author carried out randomized, double-blind study in 295 asymptomatic children infected with H. pylori[60]. Akar M, Eras Z, Oncel MY, et al. Qian B, Ma S, Shang L, Qian J, Zhang G. Effects of Helicobacter pylori eradication on gastroesophageal reflux disease. Dos Reis Buzzo Zermiani AP, de Paula Soares ALPP, da Silva Guedes de Moura BL, et al. Pediatr Infect Dis J 2002;21:411-6. Yamaoka Y. 2004 Dec;15(4):219-24. Lactobacillus acidophilus inhibits growth of Campylobacter pylori in vitro. 2006;24(10):1461-8. 2017 Oct;73(10):1199-1208. doi: 10.1007/s00228-017-2291-6. View abstract. Federal government websites often end in .gov or .mil. The beneficial effects of Lactobacillus reuteri ADR-1 or ADR-3 consumption on type 2 diabetes mellitus: a randomized, double-blinded, placebo-controlled trial. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. ns, not significant. The Lewis-like antigens (Lex , Ley, Lea, Leb) of H. pylori lipopolysaccharide are also expressed in the epithelial cells of gastric mucosa, therefore they probably play an important role in adherence to gastric cells[5]. 2020;12(3):819-823. Demonstration that L. reuteri ATCC 55730 is able to colonize the stomach and duodenum prompted studies regarding the effect of this strain on H. pylori eradication rates and the frequency of side effects[30]. Taking antibiotics along with L. reuteri can reduce the effects of L. reuteri. After induction of H. pylori infection in mice with the standard strain of H. pylori (ATCC 43504), the infected mice were treated with drug and Lactobacillus species in different groups. Lactobacillus reuteri has been shown to inhibit H. pylori in vitro and in vivo, and theoretically may play a role in eradication therapy. Zojaji et al[66] included 160 adult patients. Madsen KL, Doyle JS, Jewell LD, et al. The results of the prospective double-blind placebo-controlled studies suggest that specific probiotics, such as S. boulardii and L. johnsonni La1 probably can diminish the bacterial load, but not completely eradicate the H. pylori bacteria. Feng JR, Wang F, Qiu X, McFarland LV, Chen PF, Zhou R, Liu J, Zhao Q, Li J. Eur J Clin Pharmacol. Lactobacillus reuteri increases the amount of Treg cells in the body, which suppresses the actions of another kind of T cell called a Th17 cell (which secretes IL-17). Szajewska H, Gyrczuk E, Horvath A. Lactobacillus reuteri DSM 17938 for the management of infantile colic in breastfed infants: a randomized, double-blind,placebo-controlled trial. Francavilla R, Lionetti E, Castellaneta SP, Magistà AM, Maurogiovanni G, Bucci N, De Canio A, Indrio F, Cavallo L, Ierardi E, Miniello VL. Bethesda, MD 20894, Web Policies For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version. The eradication levels using standard triple therapy is between 60% and 80%, the last being regarded as the minimal acceptable level according to the Maastricht guidelines[23]. Impact of oral probiotics on neurodevelopmental outcomes in preterm infants. Pierce A. Probiotics Antimicrob Proteins 2021;13(6):1508-1520. Antibiotics are used to reduce harmful bacteria in the body. The Anti- Helicobacter pylori Effects of Lactobacillus acidophilus, L. plantarum, and L. rhamnosus in Stomach Tissue of C57BL/6 Mice Visc Med. Clyne M, Dolan B, Reeves EP. 2012 Nov 21;18(43):6250-4. doi: 10.3748/wjg.v18.i43.6250. Author contributions: Homan M was responsible for literature review and wrote the paper; Orel R was responsible for the critically revising the paper and making important suggestions. To avoid this interaction, take L. reuteri products at least 2 hours before or after antibiotics. 2014;99(2):F110-5. Patients were treated by the standard triple therapy for 2 weeks and either L. reuteri or placebo for 4 weeks. In addition, some probiotic strains can reduce the occurrence of side effects due to antibiotic therapy and consequently increase the H. pylori eradication rate. Peer Review reports Background The H. pylori standard antibiotic therapy fails in about 25-30% of cases, particularly because of the increasing occurrence of resistance to antibiotics. Lactobacillus reuteri strain combination in Helicobacter pylori infection: a randomized, double-blind, placebo-controlled study. the contents by NLM or the National Institutes of Health. Multiple strains probiotics appear to be the most effective probiotics in the prevention of necrotizing enterocolitis and mortality: An updated meta-analysis. Effects of oral probiotic supplements on vaginal microbiota during pregnancy: a randomised, double-blind, placebo-controlled trial with microbiome analysis. Borruel N, Casellas F, Antolín M, Llopis M, Carol M, Espíin E, Naval J, Guarner F, Malagelada JR. The major OMP is the blood group antigen-binding adhesion A (BabA), which mediates the binding of H. pylori to the fucosylated Leb blood group antigen. In spite of prolonged therapy they found no difference in H. pylori eradication rates among the yogurt and the placebo groups of patients (14/33 vs 13/32, P value is not significant). Regardless of the used probiotics the authors reported significant decrease in 13C-urea breath test values in the probiotic group of studied patients. Sgouras D, Maragkoudakis P, Petraki K, Martinez-Gonzalez B, Eriotou E, Michopoulos S, Kalantzopoulos G, Tsakalidou E, Mentis A. Pedersen AML, Bukkehave KH, Bennett EP, Twetman S. Effect of lozenges containing Lactobacillus reuteri on the severity of recurrent aphthous ulcers: a pilot study. A Taxonomic Note on the Genus Lactobacillus: Description of 23 Novel Genera, Emended Description of the Genus Lactobacillus Beijerinck 1901, and Union of Lactobacillaceae and Leuconostocaceae. J Infect Dis 1997;175:218-21. Clinical studies of probiotics in human are rapidly increasing. View abstract. J Allergy Clin Immunol 1997;99:179-85. . 2016;174:160-164.e1. Enhancing compliance not a prerequisite for effective eradication of Helicobacter pylori: the HelP Study. Study flow chart. In developed parts of the world the prevalence has lowered and is below 10% in children and below 30% in adults[11]. Diarrhoea, nausea and taste disturbance were significantly reduced in the L. GG supplemented group (relative risk = 0.1, 95%CI: 0.1 ± 0.9; relative risk = 0.3, 95%CI: 0.1 ± 0.9; relative risk = 0.5, 95%CI: 0.2 ± 0.9, respectively). The study showed that the density of bacterial load diminishes in the probiotic group of asymptomatic patients, whereas complete eradication of H. pylori was not successful. The aim of this . It has been shown that L. plantarum strain 299v increases the expression of MUC2 gene and that L. rhamnosus GG stimulates the expression of MUC3 gene and the subsequent extracellular secretion of mucin by colon cell cultures[45,46]. 2008; Scaccianoce et al. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. Keywords: In the control group 9% lover absolute eradication rate was detected (71%, 324 of the 455 patients). Gastrointestinal Symptom Rating Scale; Helicobacter pylori; Lactobacillus reuteri; eradication rate; gastritis; triple therapy. View abstract. de Los Angeles Pineda M, Thompson SF, Summers K, de Leon F, Pope J, Reid G. A randomized, double-blinded, placebo-controlled pilot study of probiotics in active rheumatoid arthritis. Am J Physiol 1999;276(4 Pt 1):G941-50. From the original discovery of genus Helicobacter, more than 20 species have now been formally defined[1]. H. pylori infection is still one of the most common bacterial infections all over the world. The authors concluded that S. boulardii can lower the bacterial load in the gastric mucosa of children infected with H. pylori bacteria. Statistically significant changes in 13C-urea breath test were observed only in the group of pediatric patients treated with live L. johnsonii La1 probiotics. Statistically significant decreases of urea breath test values were detected in two groups: the standard triple group and the S. boulardii inulin synbiotic group of children. The American Pharmaceutical Association Practical Guide to Natural Medicines. View abstract. The aim of this study was to examine the efficacy of L. reuteri in H. pylori eradication therapy. Probiotics as adjuvant therapy in Helicobacter pylori eradication protocols. 2020;65(1):12-20. The new L. reuteri ATCC 55730 strain seems to have strong anti-inflammatory properties. Mack DR, Michail S, Wei S, McDougall L, Hollingsworth MA. doi: 10.1002/14651858.CD008337.pub2. Effect of Bifidobacterium bifidum fermented milk on Helicobacter pylori and serum pepsinogen levels in humans. The authors analyse also the data of specific adverse effects. 2010;14(3):163-70. The study compared eradication rates after 3 wk of therapy with (1) placebo juice/L. 2022;14(6):1178. J Infect Dis 1998;178:446-50. Careers. Dehesa M, Larisch J, Dibildox M, Di Silvio M, Lopez LH, Ramirez-Barba E, Torres J. Clin Drug Investig. Francavilla R, Polimeno L, Demichina A, Maurogiovanni G, Principi B, Scaccianoce G, Ierardi E, Russo F, Riezzo G, Di Leo A, Cavallo L, Francavilla A, Versalovic J. J Clin Gastroenterol. Hudault S, Lievin V, Bernet-Camard MF, Servin AL. For example, L. reuteri strains, JCM 1081 and TM 105, inhibit the binding of spiral bacteria to glycolipid receptors asialo-GMI and sulfatide[48]. Lactic acid has probably an additional effect on H. pylori by lowering the pH and inhibiting the urease[40]. 2008 ]. Before Probiotics may compete directly with Helicobacter pylori, possibly by interference with adherence or by the production of antimicrobial molecules. Akram Z, Shafqat SS, Aati S, Kujan O, Fawzy A. Ghidini M, Nicoletti M, Ratti M, et al. Elliott et al[31] has observed that in a rat with active gastric ulcer the local microbiota changed toward Gram-negative bacteria including E. coli while the Lactobacullus species almost disappeared. L. reuteri is a good alternative for patients with chronic dyspepsia for the eradication of H. pylori infection and eradication was associated with improvement of dyspeptic symptoms for both eradication regimens. Van de Bovenkamp JH, Mahdavi J, Korteland-Van Male AM, Büller HA, Einerhand AW, Borén T, Dekker J. Furthermore, lover compliance due to adverse events results in higher antibiotic resistance of bacterial strains. Background and aim The eradication of H. pylori infection using PPI associated with different combinations of two or three antibiotics entails high risks of side effects and non . This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Surprisingly, in 12% of children in the second group treated with S. boulardii and inulin H. pylori even the eradication was successful. Cremonini F, Di Caro S, Covino M, Armuzzi A, Gabrielli M, Santarelli L, Nista EC, Cammarota G, Gasbarrini G, Gasbarrini A. View abstract. A combination of two L. reuteri strains or placebo was given for two months concomitantly with one-week triple eradication therapy in a second part of the study. Federal government websites often end in .gov or .mil. Cruchet S, Obregon MC, Salazar G, Diaz E, Gotteland M. Effect of the ingestion of a dietary product containing Lactobacillus johnsonii La1 on Helicobacter pylori colonization in children. FEMS Immunol Med Microbiol 1993;6:251-64. 2010;157(4):598-602. Sasaki M, Ogasawara N, Utsumi K, Kawamura N, Kamiya T, Kataoka H, Tanida S, Mizoshita T, Kasugai K, Joh T. Changes in 12-Year First-Line Eradication Rate of Helicobacter pylori Based on Triple Therapy with Proton Pump Inhibitor, Amoxicillin and Clarithromycin. View abstract. View abstract. The effect of other probiotics strains is less well described. Chau K, Lau E, Greenberg S, Jacobson S, Yazdani-Brojeni P, Verma N, Koren G.Probiotics for infantile colic: a randomized, double-blind, placebo-controlled trial investigating Lactobacillus reuteri DSM 17938. The results demonstrated that L. reuteri DSM17648 has the potential to suppress H. pylori infection, and may lead to an improvement of H. pylori -associated gastro intestinal symptoms. Lactobacilli were able to increase the local IgA concentration and decrease specific anti H. pylori IgG antibodies in animal models[37,38]. J Clin Periodontol. Eur J Dermatol 2021;31(2):225-232. Armuzzi et al[68] included 60 infected asymptomatic patients in a prospective study in which patients were treated with rabeprazole, clarithromycin tinidazole and L. GG or with the same triple therapy and placebo. Matjaž Homan, Rok Orel, University Children’s Hospital, 1000 Ljubljana, Slovenia. The secondary endpoints of the same meta-analysis were also to determine the effect of S. boulardii on therapy-related adverse effects. Reid G, Cook RL, Bruce AW. Lactobacillus reuteri, through different mechanisms including production of reuterin, has anti- H. pylori activity and has been evaluated for improving the eradication rates of H. pylori [ Hamilton-Miller, 2003] with contradictory results [ Francavilla et al. Emara MH, Mohamed SY, Abdel-Aziz HR. The metabolites can diminish the number of spiral bacteria[39]. A randomized controlled open label crossover trial to study vaginal colonization of orally administered Lactobacillus reuteri RC-14 and rhamnosus GR-1 in pregnant women at high risk for preterm labor. World J Gastroenterol 2012;18(43):6250-4. Guruge JL, Falk PG, Lorenz RG, Dans M, Wirth HP, Blaser MJ, Berg DE, Gordon JI. View abstract. J Clin Gastroenterol 2011;45(9):785-9. In vitro anti-Helicobacter pylori activity of the probiotic strain Bacillus subtilis 3 is due to secretion of antibiotics. Among them only 90 children were included. Walz A, Odenbreit S, Stühler K, Wattenberg A, Meyer HE, Mahdavi J, Borén T, Ruhl S. Identification of glycoprotein receptors within the human salivary proteome for the lectin-like BabA and SabA adhesins of Helicobacter pylori by fluorescence-based 2-D bacterial overlay.