Containing hemp seed and squalane, Herbivore's Emerald Deep Moisture Glow Oil promises to help improve skin dullness, dryness, and inflammation while, of course, delivering a healthy dose of vitamin D. Studies have shown that those with acne saw improvement after increasing vitamin D intake. Individuals who have difficulty absorbing dietary fat might therefore require vitamin D supplementation [63]. More recently, a 2022 ancillary study of the Vitamin D and Omega-3 Trial (VITAL; described in the Cancer section below) investigated whether supplemental vitamin D3 (50 mcg [2,000 IU]/day) would lower the risk of fractures in 25,871 generally healthy men aged 50 years and older and women aged 55 years and older over a median follow-up of 5.3 years [82]. Levels of 50 nmol/L (20 ng/mL) or more are sufficient for most people. In contrast, the United Kingdom government recommends intakes of 10 mcg (400 IU)/day for its citizens aged 4 years and older [16]. In a cohort of 4,733 men, of which 1,731 had prostate cancer, those with 25(OH)D levels of 45–70 nmol/L (18–28 ng/mL) had a significantly lower risk of the disease than men with either lower or higher values [109]. An analysis of NHANES 2011–2014 data on serum 25(OH)D levels found that most people in the United States aged 1 year and older had sufficient vitamin D intakes according to the FNB thresholds [43]. Very limited evidence suggests no substantial differences in the bioavailability of vitamin D from various foods [19]. Neither aging nor obesity alters vitamin D absorption from the gut [4]. The study included 25,871 men aged 50 years and older and women aged 55 years and older who had no history of cancer, and most had adequate serum 25(OH)D levels at baseline. However, the supplementation had no significant effects on fasting blood glucose, hemoglobin A1c, or fasting insulin levels. Vitamin D might be involved in the pathophysiology of type 2 diabetes through its effects on glucose metabolism and insulin signaling as well as its ability to reduce inflammation and improve pancreatic beta-cell function [1443,145]. 2016;11(8):e0161162. Although 25(OH)D functions as a biomarker of exposure, the extent to which 25(OH)D levels also serve as a biomarker of effect on the body (i.e., relating to health status or outcomes) is not clear [1,3]. Vitamin D compounds in the body are exogenously derived by dietary means; from plants as 25-hydroxyvitamin D2 (ergocalciferol or calciferol) or from animal products as 25-hydroxyvitamin D3 (cholecalciferol or calcidiol). Obes Rev 2014;15:528-37. [, Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A. Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. Cancer Epidemiol Biomarkers Prev 2014;23:1220-9. Am J Clin Nutr 2004;80:1710S-6S. [, Tripkovic L, Lambert H, Hart K, Smith CP, Bucca G, Penson S, et al. - Hautverträglichkeit medizinisch bestätigt, für empfindliche Haut geeignet. MS is an autoimmune disease of the central nervous system that damages the myelin sheath surrounding and protecting nerve cells in the brain and spinal cord. Glucocorticoid-induced osteoporosis: pathogenesis and management. More information about assay standardization is available from the Vitamin D Standardization Program webpage. Vitamin D in cutaneous carcinogenesis: part II. As Zeichner explains it, our bodies naturally make vitamin D in response to sun exposure. J Clin Endocrinol Metab 2016;101:1647-55. In a subsequent investigation for 4.9 years after the study's end, women who had taken the vitamin D and calcium supplements (many of whom continued to take them) still had the same colorectal cancer risk as those who received placebo [100]. Yes. J Clin Endocrinol Metab 2011;96:3838-45. The groups showed no significant differences in measures of muscle strength or performance [85]. Vitamin D is involved in various brain processes, and vitamin D receptors are present on neurons and glia in areas of the brain thought to be involved in the pathophysiology of depression [130]. The fortification of milk (a good source of calcium) and other staples, such as breakfast cereals and margarine, with vitamin D beginning in the 1930s along with the use of cod liver oil made rickets rare in the United States [28,50]. JAMA 2018;319:1630. Cancer
Includes a variety of protein foods such as lean meats; poultry; eggs; seafood; beans, peas, and lentils; nuts and seeds; and soy products. Cochrane Database Syst Rev 2014; 23(6):CD007469. A study of cohorts that included 5,313 participants who developed lung cancer and 5,313 matched controls found no association between serum 25(OH)D levels and risk of subsequent lung cancer, even when the investigators analyzed the data by sex, age, race and ethnicity, and smoking status [104]. The existing evidence suggests vitamin D may have beneficial effects on serum lipid profiles and thus cardiovascular health. Another reason is that animal foods contain some 25(OH)D. This form of vitamin D is not included in intake surveys and is considerably more potent than vitamins D2 or D3 at raising serum 25(OH)D levels [42]. One study comparing 738 men who developed pancreatic cancer to 738 matched controls found no relationship between serum 25(OH)D levels and risk of pancreatic cancer [105]. Arterioscler Thromb Vasc Biol 2012;32:2794-802. No studies have evaluated whether vitamin D supplements may benefit individuals under medical care for clinical depression who have low or deficient 25(OH)D levels and are taking antidepressant medication. The vitamin D3 and calcium supplements did not reduce breast cancer incidence, and 25(OH)D levels at the start of the study were not associated with breast cancer risk [99]. Monthly high-dose vitamin D supplementation does not increase kidney stone risk or serum calcium: Results from a randomized controlled trial. A dose-response analysis found that each 20 nmol/L [8 ng/mL] increase in 25(OH)D was associated with a 9% lower risk of both all-cause and prostate cancer-specific mortality. [, Holick MF. Beef liver, egg yolks, and cheese have small amounts of vitamin D, primarily in the form of vitamin D3 and its metabolite 25(OH)D3. Ann Oncol 2018;29:1468-75. National Institutes of Health Osteoporosis and Related Bone Diseases National Resource Center. One clinical trial randomized 260 Black women aged 60 years and older (mean age 68.2 years) to receive 60 to 120 mcg (2,400 to 4,800 IU) per day vitamin D3 supplementation to maintain serum 25(OH)D levels above 75 nmol/L (30 ng/mL) for 3 years [84]. Some observational studies show associations between low serum levels of 25(OH)D and increased risks of cancer incidence and death. Vitamin D obtained from sun exposure, foods, and supplements is biologically inert and must undergo two hydroxylations in the body for activation. No substantial between-group differences in fracture incidence were found by race, ethnic group, BMI, age, baseline 25(OH)D levels, or whether participants took supplemental calcium, were at high fracture risk, or had a history of fragility fractures. The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Rickets. N Engl J Med 2006;354:669-82. Questions or comments about our tests and resources? Effect of vitamin D supplementation on serum lipid profiles: A systematic review and meta-analysis. Vitamin D3 is the more common form. [, Seida JC, Mitri J, Colmers IN, Majumdar SR, Davidson MB, Edwards AL, et al. 2019 Mar;68(3):475-486. Most trials of the effects of vitamin D supplements on bone health also included calcium supplements, so isolating the effects of each nutrient is difficult. N Eng J Med 2022;387:299-309. Circulating vitamin D concentrations and risk of breast and prostate cancer: A Mendelian randomization study. Ann Intern Med 2014;160:558-64. Plasma vitamin D and prostate cancer risk: Results from the Selenium and Vitamin E Cancer Prevention Trial. [, Galior K, Grebe S, Singh R. Development of vitamin D toxicity from overcorrection of vitamin D deficiency: A review of case reports. Collection Instructions: Centrifuge and aliquot serum into a plastic vial. Similarly, the VITAL clinical trial described above found that vitamin D supplements did not significantly decrease rates of heart attacks, strokes, coronary revascularization, or deaths from cardiovascular causes [93]. [, Ekwaru JP, Zwicker JD, Holick MF, Giovannucci E, Veugelers PJ. Tolerable Upper Intake Level (UL): Maximum daily intake unlikely to cause adverse health effects. doi:10.1016/j.jaad.2012.07.022, Lim SK, Ha JM, Lee YH, et al. Ann Intern Med 2015;162:133-40. The effect of vitamin D supplementation on prostate cancer: A systematic review and meta-analysis of clinical trials. Does a vitamin D deficiency contribute to acne? Vitamin D 20 000 IU per week for five years does not prevent progression from prediabetes to diabetes. Cancer Epidemiol Biomarkers Prev 2014;23:1484-93. BMC Public Health 2017;17:519. In adults and adolescents, vitamin D deficiency can lead to osteomalacia, in which existing bone is incompletely or defectively mineralized during the remodeling process, resulting in weak bones [46]. The FNB committee that established DRIs for vitamin D found that the evidence was inadequate or too contradictory to conclude that the vitamin had any effect on a long list of potential health outcomes (e.g., on resistance to chronic diseases or functional measures), except for measures related to bone health. In contrast, another meta-analysis of 30 clinical trials in 4,744 participants (mean age 54.5 years) that administered 5 mcg (200 IU) to 300 mcg (12,000 IU)/day vitamin D3 for a mean of 5.6 months showed that more than 20 mcg (800 IU)/day significantly reduced systolic and diastolic blood pressure in normal-weight participants who had hypertension [128]. However, according to Williams, studies on the benefits of topical vitamin D for normal skin health are lacking. But, always check with your physician and discuss any supplements or vitamins before adding them to your regimen. Elsevier, 2018. Although UVB exposure can produce vitamin D in infants, the American Academy of Pediatrics (AAP) advises parents to keep infants younger than 6 months out of direct sunlight, dress them in protective clothing and hats, and apply sunscreen on small areas of exposed skin when sun exposure is unavoidable [59]. PERSONAL COACHING anfragen: https://sennfit.de/terminanfrage/Mein kleiner SHOP für dich: https://sennfit.de/shop/mehr zum Thema GANZHEITLICH FIT leben: https. Some people take very high doses of vitamin D supplements. Vitamin D and bone density, fractures, and falls: The end of the story? [, Guirguis-Blake JM, Michael YL, Perdue LA, Coppola EL, Beil TL. The FNB recommended avoiding serum 25(OH)D levels above approximately 125–150 nmol/L (50–60 ng/mL), and it found that even lower serum levels (approximately 75–120 nmol/L [30–48 ng/mL]) are associated with increases in rates of all-cause mortality, risk of cancer at some sites (e.g., pancreas), risk of cardiovascular events, and number of falls and fractures among older adults. Serum vitamin D and risk of breast cancer within five years. Is hypovitaminosis D related to incidence of type 2 diabetes and high fasting glucose level in healthy subjects: A systematic review and meta-analysis of observational studies. [, Li X, Liu Y, Zheng Y, Wang P, Zhang Y. [, Brondum-Jacobsen P, Benn M, Jensen GB, Nordestgaard BG. Some mushrooms available on the market have been treated with UV light to increase their levels of vitamin D2. IOM committee members respond to Endocrine Society vitamin D guidelines. 25-hydroxyvitamin D deficiency and risk of MS among women in the Finnish Maternity Cohort. The AAP also recommends 10 mcg (400 IU)/day supplemental vitamin D for all infants who are not breastfed and ingest less than 1,000 mL/day vitamin D-fortified formula or milk. Because vitamin D is fat soluble, its absorption depends on the gut’s ability to absorb dietary fat [4]. [, Bjelakovic G, Gluud LL, Nikolova D, Whitfield K, Krstic G, Wetterslev J, Gluud C. Vitamin D supplementation for prevention of cancer in adults. Long-term vitamin D3 supplementation is more effective than vitamin D2 in maintaining serum 25-hydroxyvitamin D status over the winter months. Vitamin D, Volume 2: Health, Disease and Therapeutics, Fourth Edition. [, Munns CF, Shaw N, Kiely M, Specker BL, Thacher TD, Ozono K, et al. If using a topical vitamin D prescription, follow the application instructions from your doctor. Since 2014, however, several published studies and meta-analyses have found no relationship between 25(OH)D levels and prostate cancer risk [111,112]. Effects of orlistat on fat-soluble vitamins in obese adolescents. [, Weisberg P, Scanlon KS, Li R, Cogswell ME. Journal of Nutrition Science 2018;7:1-7. No association between vitamin D supplementation and risk of colorectal adenomas or serrated polyps in a randomized trial. RDAs for vitamin D are listed in both micrograms (mcg) and international units (IU); 1 mcg vitamin D is equal to 40 IU (Table 2). Guidelines on vitamin D replacement in bariatric surgery? Am J Clin Nutr 2019;110:1119-30. To sit outside in the sun or not to sit outside in the sun—that is the perennial question we ask ourselves when torn between protecting our skin from UV damage or getting our recommended daily amount of vitamin D. But with all the other methods available, like through diet, oral supplements, or topicals, how necessary is baking in the sun? Bone health and osteoporosis
[, Vaes AMM, Tieland M, Toussaint N, Nilwik R, Verdijk LB, van Loon LJC, de Groot CPGM. Gut. Vitamin D, calcium, or combined supplementation for the primary prevention of fractures in community-dwelling adults. If you choose to use a topical vitamin D for anti-aging, Herrmann says combining it with other antioxidant vitamins, growth factors, or retinoids can create a "super" product, working on multiple anti-aging pathways. In 2013–2014, an estimated 3.2% of the U.S. adult population took supplements containing 100 mcg (4,000 IU) or more vitamin D [41]. Mehr als nur ein Gesichtsserum. This process, regulated by parathyroid hormone (PTH), might increase DHVD synthesis at the expense of the alternative hydroxylation (CYP24A1) product 24,25D. Damit du genau weißt, welches Serum dein momentanes Hautproblem am besten lösen kann, haben wir dir eine Übersicht erstellt, die zeigt, welche Seren für welche Hautbedürfnisse am besten geeignet sind. J Natl Cancer Inst 2007;100:1581-91. Save 10% with coupon. Further research is needed to determine whether vitamin D inadequacy increases cancer risk, whether greater exposure to the nutrient can prevent cancer, and whether some individuals could have an increased risk of cancer because of their vitamin D status over time. Association of serum level of vitamin D at diagnosis with breast cancer survival: A case-cohort analysis in the Pathways Study. J Natl Cancer Inst 2019;111:158-69. Daily supplementation with 15 µg vitamin D2 compared with vitamin D3 to increase wintertime 25-hydroxyvitamin D status in healthy South Asian and white European women: A 12-wk randomized, placebo-controlled food-fortification trial. [, Rooney MR, Harnack L, Michos ED, Ogilvie RP, Sempos CT, Lutsey PL. Weight loss
Ninth edition. In one meta-analysis of 46 clinical trials that included 4,541 participants, vitamin D supplements (typically 40 mcg [1,600 IU]/day or less) for a minimum of 4 weeks had no significant effects on systolic or diastolic blood pressure [127]. The British Journal of Psychiatry 2013;202:100-7. [, Aloia JF, Li-Ng M, Pollack S. Statins and vitamin D. Am J Cardiol 2007;100:1329. Am J Clin Nutr 2004;80:1697S-705S. However, higher serum 25(OH)D levels (at a cut point of 75 nmol/L [30 ng/mL]) were linked to a modestly higher risk of slow-growth prostate cancer and a more substantial lower risk of aggressive disease. Yao P, Bennett D, Mafham M, Lin X, Chen Z, Armitage J, Clarke R. Vitamin D and calcium for the prevention of fracture: A systematic review and meta-analysis. J Natl Cancer Inst 2007;99:1563-5. Ready-to-eat breakfast cereals often contain added vitamin D, as do some brands of orange juice, yogurt, margarine, and other food products. Clinical trial evidence on older adults
Individuals with obesity who have undergone gastric bypass surgery can also become vitamin D deficient. Preventive Medicine 2013;57:753-64. [, Zhang R, Li B, Gao X, Tian R, Pan Y, Jiang Y, et al. N Engl J Med 2006;354:684-96. [, Gotfredsen A, Westergren Hendel H, Andersen T. Influence of orlistat on bone turnover and body composition. In addition, the Food and Drug Administration (FDA) has approved UV-treated mushroom powder as a food additive for use as a source of vitamin D2 in food products [18]. However, frequent use of tanning beds, which provide artificial UV radiation, can lead to 25(OH)D levels well above 375–500 nmol/L (150–200 ng/mL) [158-160]. Vitamin D alone did not significantly affect the development of new serrated polyps, but the combination of vitamin D with calcium increased the risk almost fourfold. Dhingra says the chief function of vitamin D is maintaining a calcium balance in our bodies, but it also has functions well beyond this—for instance, the role it plays in skin health. Those looking to fight inflammatory skin diseases can consider a prescription topical. Vitamin D is a fat-soluble prohormone with several forms. FREE delivery Mon, Jun 5 on $25 of items shipped by Amazon. [, Travis RC, Perez-Cornago A, Appleby PN, Albanes D, Joshu CE, Lutsey PL, et al. However, the amount you need to produce adequate vitamin D is quite low. The FNB established ULs for vitamin D in 2010 (Table 4) [1]. [, James WP, Avenell A, Broom J, Whitehead J. [, Jiang X, Dimou NL, Al-Dabhani K, Lewis SJ, Martin RM, Haycock PC, et al. Rates of breast, prostate, and colorectal cancer did not differ significantly between the vitamin D and placebo groups. Some patients with granulomatous diseases (eg, sarcoidosis) and malignancies containing nonregulated 1-alpha hydroxylase in the lesion might have hypercalcemia that appears vitamin D mediated with normal or high serum phosphate (hyperphosphatemia) and hypercalcemia (both of which might be severe) in addition to low PTH and absent parathyroid hormone-related peptide (PTHRP). [, Shea MK, Fielding RA, Dawson-Hughes B. Corticosteroid medications, such as prednisone (Deltasone®, Rayos®, and Sterapred®), are often prescribed to reduce inflammation. However, FoodData Central does not include the amounts of 25(OH)D in foods. [, Buckley LM, Leib ES, Cartularo KS, Vacek PM, Cooper SM. [. Role of vitamin D in atherosclerosis. Older women and men should consult their health care providers about their needs for both nutrients as part of an overall plan to maintain bone health and to prevent or treat osteoporosis. Taken together, studies to date do not indicate that vitamin D with or without calcium supplementation reduces the incidence of cancer, but adequate or higher 25(OH)D levels might reduce cancer mortality rates. Objective: The objective of this systematic review and meta-analysis was to examine the effect of vitamin D supplementation on serum lipid profiles. These medications can reduce calcium absorption and impair vitamin D metabolism [171-173]. In the NHANES 2001–2006 survey, 25(OH)D deficiency (less than 25 nmol/L [10 ng/mL]) was more than twice as common among children and adults who reported oral steroid use (11%) than in nonusers (5%) [174].